Known as the Insurance Capital of the World, Hartford is a high-ranked city for economic measures and a growing city of entrepreneurship.

Tucson AZ, known as “Optics Valley” is growing into a substantial city for innovation and business, and is attracting many large manufacturing companies.

Long known as a transportation hub that earned both the city itself and the state as a whole the nickname “Crossroads of America,” Indianapolis’ strong economy makes it an attractive destination for entrepreneurs.

Home multiple automobile manufacturing companies, Detroit has earned the nickname the Motor City. Despite filing for bankruptcy in 2013, the city has recovered and is becoming a hotspot for entrepreneurship and innovation.

Buffalo, NY, named after the nearby Buffalo Creek, is New York’s second-largest city and perhaps the major connection point between the United States and Canada. Nicknamed “the City of Light” for its early adoption of electricity, that entrepreneurial and enterprising spirit carries on to this day.

A shipping hub, Little Rock hosts the headquarters of some major companies such as Dillard’s. The city also has a burgeoning entrepreneurship scene…

Thanks in part to its status as the home of the University of Michigan, Ann Arbor is ranked as the most-educated city in the world. Perhaps because of that high level of education, Ann Arbor is considered a good place for entrepreneurship.

Known primarily as a cultural destination, New Orleans’ status as a port city has long made it one of the region’s premier economic hubs. Home to some more-established businesses, the city is also the third-youngest entrepreneurship scene in the country.

Known as America’s first boomtown, Rochester is home to a number of well-known businesses, including Kodak and Western Union. More recently, Rochester has become known as a place for new ventures and entrepreneurship.

Charleston, SC consistently ranks as one of best cities in the world. Also deemed as one of the fastest growing cities since 2010, Charleston has become a hot spot for startups who’ve raised over $10 million in funding.