Centrally-located city near a number of famous landmarks, Flagstaff is perhaps best known for its tourism economy. That said, the city is home to several manufacturing and medical technology companies in addition to major observatories.

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Known as the Insurance Capital of the World, Hartford is a high-ranked city for economic measures and a growing city of entrepreneurship.

One of the oldest cities in the nation, Philadelphia has a history as an important political and business hub; that said, it is still home to a number of established businesses – most notably Comcast – and startups alike.

Pittsburgh, aka the Steel City, is the is the second largest city in Pennsylvania and is an up and coming tech hub to watch in the U.S.

The curse of the entrepreneur: you have this great idea and it looks like it will do really well. The problem? You lack the capital and the skill to build it. What’s the solution? Giving Away Startup Ownership.

Nicknamed the “Pittsburgh of the South,” Birmingham continues to be home to a number of well-known companies, especially those involved in steel or iron production such as McWane or O’Neal Steel.

Known primarily as a cultural destination, New Orleans’ status as a port city has long made it one of the region’s premier economic hubs. Home to some more-established businesses, the city is also the third-youngest entrepreneurship scene in the country.

Known as America’s first boomtown, Rochester is home to a number of well-known businesses, including Kodak and Western Union. More recently, Rochester has become known as a place for new ventures and entrepreneurship.

US News & World Report ranked Georgia as the ninth-most active state for entrepreneurship, with Savannah becoming a top city for African-American owned businesses.

Baton Rouge may be Louisiana’s state capital, but it’s gaining notoriety as a diverse focal-point for entrepreneurship. The city has been recognized as a growing ecosystem for Women, Hispanic, and African-American entrepreneurs.