Milwaukee may be known as the home to multiple breweries, but Wisconsin’s largest city is establishing itself as a hub for Midwest entrepreneurship.

Nicknamed the “City of Trees” and perhaps best-known as home to potato farmers, Boise is a budding place for entrepreneurship and small business.

Tucson AZ, known as “Optics Valley” is growing into a substantial city for innovation and business, and is attracting many large manufacturing companies.

Long known as a transportation hub that earned both the city itself and the state as a whole the nickname “Crossroads of America,” Indianapolis’ strong economy makes it an attractive destination for entrepreneurs.

Home multiple automobile manufacturing companies, Detroit has earned the nickname the Motor City. Despite filing for bankruptcy in 2013, the city has recovered and is becoming a hotspot for entrepreneurship and innovation.

The Entertainment Capital of the World, Las Vegas is also home to several major companies – especially gambling-based ones.

Buffalo, NY, named after the nearby Buffalo Creek, is New York’s second-largest city and perhaps the major connection point between the United States and Canada. Nicknamed “the City of Light” for its early adoption of electricity, that entrepreneurial and enterprising spirit carries on to this day.

One of the oldest cities in the nation, Philadelphia has a history as an important political and business hub; that said, it is still home to a number of established businesses – most notably Comcast – and startups alike.

A shipping hub, Little Rock hosts the headquarters of some major companies such as Dillard’s. The city also has a burgeoning entrepreneurship scene…

Thanks in part to its status as the home of the University of Michigan, Ann Arbor is ranked as the most-educated city in the world. Perhaps because of that high level of education, Ann Arbor is considered a good place for entrepreneurship.